Sun Lab | MS-Based Structural Proteomics at UTK

We develop advanced mass spectrometry–based structural proteomics platforms to investigate protein structure and dynamics in native environments. We focus on: (1) integral membrane proteins embedded in their physiological lipid contexts, and (2) intrinsically disordered proteins such as Tau. By integrating chemical footprinting, in situ labeling strategies, and multi-modal MS analysis, we aim to decode the high-order structures of those sensitive proteins and facilitate the understanding of disease mechanisms and drug development.